An imbalance in any of the four areas above can be manifested as a headache. For example, a person suffering from COPD may experience frequent headaches as a result of poor oxygenation. Likewise, a person with diabetes will experience a headache when their blood sugar is out of a nominal range. Inflammation can impinge on nervous tissues resulting in over activation. At the same time inflammation can constrict blood vessels and restrict blood flow carrying the needed oxygen a